Induced Pluripotent Stem Cells

The best proven approaches to creating new beating heart cells are using embryonic stem cells, induced pluripotent cells and heart-derived stem cells.

最好的受到证明的产生新生心肌细胞的方法是利用胚胎干细胞，包括多潜能细胞和心脏衍生细胞。

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Induced pluripotent stem cells ( iPS cells) were derived from somatic cells by introducing specific transcription factors, which made somatic cells reprogrammed. The emergence of iPS cells was a revolution in life science.

诱导多能干细胞（induced pluripotent stem cells，简称iPS cells）是通过将特定的转录因子导入分化的体细胞重编程而成，它的出现是生命科学领域的一次革命。

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Currently, there are three types of human pluripotent stem cells available for study: embryonic stem cells ( ESCs), embryonic germ cells ( EGCs), and induced pluripotent stem cells ( iPS).

目前，人多能性干细胞包括三种类型：人胚胎干细胞（ESC）、人胚胎生殖细胞（EGC）和人诱导多能性干细胞（iPS）。

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Somatic cells can be reprogrammed to induced pluripotent stem cells ( iPSCs) by ectopic expression of defined transcriptional factors. The efficiency of this process, however, is extremely low.

通过异位表达外源的4个转录因子能够诱导体细胞重编程为诱导多能干细胞（iPSCs），但是诱导iPS产生的效率很低。

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Induced pluripotent stem cells ( iPSCs) can self-renew and differentiate into almost all cell types in vitro and in vivo, which have great application potential in regenerative medicine and high vaule in theoretic research.

多能干细胞能够自我更新，能在体内外分化成几乎所有类型的细胞，在再生医学等方面有巨大的应用潜力，具有极高的理论研究价值。

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The study would create a human pancreas in rodents using human induced pluripotent stem ( iPS) cells.

这项研究将利用人类诱导多能干细胞（iPS）在啮齿动物体内形成人类胰腺。

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The pluripotent cells produced by this technology are named induced pluripotent stem cells ( iPSCs).

诱导多能干细胞技术产生的多能干细胞被称为诱导型多能干细胞。

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The human induced pluripotent stem cells can differentiate into the epidermal-like stem cells by amniotic membrane in vitro.

在羊膜诱导下人诱导性多能干细胞可定向分化为表皮样干细胞，具有作为皮肽组织工程种子细胞新来源的潜能。

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However, making the appropriate cells via induced pluripotent stem cells ( iPSCs) requires reprogramming of somatic cells and subsequent redifferentiation.

然而，从IPS细胞制造合适的细胞将需要体细胞的重编程和随后的再分化。

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No matter in petri dishes or on microfluidic chip, undifferentiated human induced pluripotent stem cells have the positive alkaline phosphatase ( AKP) staining, which illustrates that establishing a stable culture system of iPS cells on microfluidic chip is feasible. 5.

普通培养皿和微流控芯片中未分化的人诱导多能干细胞碱性磷酸酶（AKP）染色均呈阳性，说明在微流控芯片中能建立稳定的人iPS细胞培养体系。

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Yap is inactivated during mouse embryonic stem cell differentiation and activated in induced pluripotent stem ( iPS) cells.

Yap在小鼠胚胎干细胞分化过程中是被抑制甚至是失活的，但是在诱导多能干细胞（iPS）的过程中是被激活而且高表达。

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One further complication over the past two years has been the discovery and rapid refinement of "induced pluripotent" stem cells.

过去两年里，一个更复杂的问题是对“诱导多能性”干细胞的发现和提纯。

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Finally, by introducing four defined transcription factors into pig fetal fibroblasts and ovarian epithelial cells via retroviral transduction, the two types of cell have been induced into pluripotent stem cells and the reprogramming efficiencies were compared.

最后，利用包装好的逆转录病毒将4种特定的转录因子导入猪胎儿成纤维细胞及猪卵巢表皮上皮细胞，对其进行重编程诱导产生干细胞，并比较其重编程效率。

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Induced Pluripotent Stem Cells ( iPS Cells): Current Status and Future Prospect

诱导性多潜能干细胞（iPS cells）&现状及前景展望

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Conclusion: The cultured induced pluripotent stem cells grew well and stability with similar characteristics of human embryonic stem cells.

结论：在本培养体系条件下培养的人诱导性多能干细胞生长稳定，其生物学特性与人胚胎干细胞相似。

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Medical applications of induced pluripotent stem cells called into question.

诱导多能干细胞的医学应用的质疑。

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There has been great excitement over the past year about the new technology of induced pluripotent stem cells, which are created directly from adult cells without the need to make embryonic stem cells.

在过去的一年，诱导式多能干细胞（induced pluripotent stem cells）这项新技术引起了巨大的轰动。这种细胞直接从成熟细胞中生成，不需要制造胚胎干细胞。

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These induced pluripotent stem cells are cells which are returned to a very early, undifferentiated stage.

这些干细胞是早期的、未分化的细胞。

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Chimera technique is very important in developmental biology research, chimeric offspring has become the accreditation standards that validated the developmental potential of pluripotent stem cells ( embryonic stem cells, induced pluripotent stem cells).

嵌合体是发育生物学研究非常重要的技术手段，同时嵌合体发育，尤其是生殖系嵌合已经成为多能性干细胞（胚胎干细胞、诱导性多能干细胞）发育潜能的重要鉴定标准。

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We designed and fabricated a glass-glass microfluidic chip and a PDMS-glass microfluidic chip, and cultured mouse embryonic fibroblast and human induced pluripotent stem cells on the chip, which provided a basis for further study of stem cells differentiation on chips. 4.

设计并制作了玻璃-玻璃微流控芯片和PDMS玻璃微流控芯片，并在其上培养了小鼠胚胎成纤维细胞和人诱导多能干细胞，为在芯片上进行进一步的干细胞分化研究提供了基础。

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Induced pluripotent stem cells are derived from somatic cells with defined transcriptional factors.

诱导性多能性干细胞是在体细胞中转入特定的转录因子诱导而来。

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The Application Prospect of Induced Pluripotent Stem Cells in Animal Husbandry Production

诱导多功能干细胞在畜牧业生产中应用的研究进展

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Differentiation of embryonic stem cells and induced pluripotent stem cells into cardiomyocytes: progresses and perspectives

胚胎干细胞及诱导多能干细胞向心肌细胞分化和调控的研究进展

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These so-called induced pluripotent stem cells, or IPS cells, could now become any cell.

这种“诱导多功能干细胞”(简称IPS细胞)也能变成其它细胞.

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Results showed that we only got induced pluripotent stem cells with goat ear fibroblasts feeder and there were no differences between treatments with different chemicals.

结果显示，只有山羊耳尖成纤维细胞饲养层条件下诱导得到iPS细胞，而不同化学物质处理对于iPS细胞的诱导没有起到明显效果。

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MiR-145 can not only induced that pluripotent stem cells change into vascular smooth muscle cells, but also regulate the smooth muscle cells in the state of differentiation.

miR-145不仅具有诱导多能干细胞分化为血管平滑肌细胞的功能，且能调控平滑肌细胞使其处于分化状态。

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Exploring the characteristics of human induced pluripotent stem cells clone, we established a culture system of human induced pluripotent stem cells and successfully recovered the cell after cryopreserved in vitro. 3.

通过摸索人诱导多能干细胞克隆的特性，在体外建立了稳定的人诱导多能干细胞培养体系，并将其冻存后成功复苏。

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With the advent of the induced pluripotent stem cells technique a new and potentially better source for transplantable cells may be available in future.

随着诱导多能干细胞技术的问世，在将来可能提供更好的移植细胞来源。

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Or have iPS cells ( induced pluripotent stem cells) simply added a new dimension to the legal, social and ethical debates that are an important and necessary part of stem-cell advances.

万能肝细胞的只是在法律，社会，伦理添加了新的问题，这也是干细胞发展的一个重要部分。

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Looming of the Era for the Induced Pluripotent Stem Cells by Direct Nuclear Reprogram

直接重整细胞核程序的诱导性多能干细胞研究进展

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